S6K1 deficiency protects against apoptosis in hepatocytes.

  title={S6K1 deficiency protects against apoptosis in hepatocytes.},
  author={Agueda Gonz{\'a}lez-Rodr{\'i}guez and Javier Alba and Valeri Zimmerman and Sara C. Kozma and Angela M Valverde},
  volume={50 1},
UNLABELLED The mammalian target of rapamycin (mTOR)/S6K1 signaling pathway controls cell growth and proliferation. To assess the importance of S6K1 in the balance between death and survival in the liver, we have generated immortalized hepatocyte cell lines from wild-type and S6K1-deficient (S6K1(-/-)) mice. In S6K1(-/-) hepatocytes, caspase-8 and the pro… CONTINUE READING