S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.

@article{Kim2009S5aPP,
  title={S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.},
  author={Hyoung Tae Kim and Kwang Pyo Kim and Tomoaki Uchiki and Steven P Gygi and Alfred L Goldberg},
  journal={The EMBO journal},
  year={2009},
  volume={28 13},
  pages={1867-77}
}
Ubiquitin (Ub)-protein conjugates formed by purified ring-finger or U-box E3s with the E2, UbcH5, resist degradation and disassembly by 26S proteasomes. These chains contain multiple types of Ub forks in which two Ub's are linked to adjacent lysines on the proximal Ub. We tested whether cells contain factors that prevent formation of nondegradable conjugates and whether the forked chains prevent proteasomal degradation. S5a is a ubiquitin interacting motif (UIM) protein present in the cytosol… CONTINUE READING

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