S43. Dendritic cell vaccination combined with CTLA4 blockade


Background Electroporation of DC with mRNA also allows the loading of these cells with tumor antigens and the functional modification of the cellular vaccine. To this goal, we provide three different molecular adjuvants to immature, monocyte derived DCs through electroporation with mRNA coding for CD40L, CD70 and caTLR4 or so-called TriMix mRNA. At our… (More)


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