S33138 [N-[4-[2-[(3aS,9bR)-8-Cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a Preferential Dopamine D3 versus D2 Receptor Antagonist and Potential Antipsychotic Agent. II. A Neurochemical, Electrophysiological and Behavioral Characterization in Vivo

@article{Millan2008S33138A,
  title={S33138 [N-[4-[2-[(3aS,9bR)-8-Cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a Preferential Dopamine D3 versus D2 Receptor Antagonist and Potential Antipsychotic Agent. II. A Neurochemical, Electrophysiological and Behavioral Characterization in Vivo},
  author={M. Millan and P. Svenningsson and C. Ashby and M. Hill and M. Egeland and A. Dekeyne and M. Brocco and B. Di Cara and F. Lejeune and N. Thomasson and C. Muńoz and E. Moca{\"e}r and A. Crossman and L. Cistarelli and S. Girardon and L. Iob and S. Veiga and A. Gobert},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={324},
  pages={600 - 611}
}
The novel benzopyranopyrrolidine, S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], is a preferential antagonist of cloned human D3 versus D2L and D2S receptors. In mice, S33138 (0.04–2.5 mg/kg i.p.) increased levels of mRNA encoding c-fos in D3 receptor-rich Isles of Calleja and nucleus accumbens more potently than in D2 receptor-rich striatum. Furthermore, chronic (3 weeks) administration of S33138 to rats reduced the number… Expand
The role of dopamine D(3) receptors in antipsychotic activity and cognitive functions.
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