S1P1 receptor inhibits kidney epithelial mesenchymal transition triggered by ischemia/reperfusion injury via the PI3K/Akt pathway.

@article{Wang2018S1P1RI,
  title={S1P1 receptor inhibits kidney epithelial mesenchymal transition triggered by ischemia/reperfusion injury via the PI3K/Akt pathway.},
  author={Wei-Na Wang and Aimei Wang and Guochang Luo and Fengqiao Ma and Xiaoming Wei and Yongyi Bi},
  journal={Acta biochimica et biophysica Sinica},
  year={2018},
  volume={50 7},
  pages={
          651-657
        }
}
Ischemia/reperfusion (I/R) is a major cause of acute kidney injury (AKI), along with delayed graft function, which can trigger chronic kidney injury by stimulating epithelial to mesenchymal transition (EMT) in the kidney canaliculus. Sphingosine 1-phosphate receptor 1 (S1P1) is a G protein-coupled receptor that is indispensable for vessel homeostasis. This… CONTINUE READING