S1P Signalling Differentially Affects Migration of Peritoneal B Cell Populations In Vitro and Influences the Production of Intestinal IgA In Vivo

@inproceedings{Kleinwort2018S1PSD,
  title={S1P Signalling Differentially Affects Migration of Peritoneal B Cell Populations In Vitro and Influences the Production of Intestinal IgA In Vivo},
  author={Annabel Kleinwort and Felix L{\"u}hrs and Claus-Dieter Heidecke and Martin Lipp and Tobias Schulze},
  booktitle={International journal of molecular sciences},
  year={2018}
}
Introduction: Sphingosine-1-phosphate (S1P) regulates the migration of follicular B cells (B2 cells) and directs the positioning of Marginal zone B cells (MZ B cells) within the spleen. The function of S1P signalling in the third B cell lineage, B1 B cells, mainly present in the pleural and peritoneal cavity, has not yet been determined. Methods: S1P receptor expression was analysed in peritoneal B cells by real-time polymerase chain reaction (qPCR). The chemotactic response to S1P was studied… CONTINUE READING

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Sphingolipids and their metabolism in physiology and disease

Nature Reviews Molecular Cell Biology • 2018
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