S14080, a peripheral analgesic acting by release of an endogenous circulating opioid‐like substance

  title={S14080, a peripheral analgesic acting by release of an endogenous circulating opioid‐like substance},
  author={S. Ferreira and B. B. Lorenzetti and M. Devissaguet and D. Lesieur and Y. Tsouderos},
  journal={British Journal of Pharmacology},
  • S. Ferreira, B. B. Lorenzetti, +2 authors Y. Tsouderos
  • Published 1995
  • Chemistry, Medicine
  • British Journal of Pharmacology
  • 1 The oral administration of a benzothiazolinone derivative (benzoyl‐6 dihydro‐2,3 benzothiazole), S14080, caused dose‐dependent antinociception in the rat paw pressure test, which represents a model of mechanical hyperalgesia. S14080 had no significant effect on the inflammatory oedema induced by carrageenin or on the tail flick test, nor did it possess a notable antipyretic effect. 2 Post‐treatment with S14080 dose‐dependently antagonized the hyperalgesia induced by prostaglandin E2… CONTINUE READING
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