S100C/A11 is a key mediator of Ca2+-induced growth inhibition of human epidermal keratinocytes

  title={S100C/A11 is a key mediator of Ca2+-induced growth inhibition of human epidermal keratinocytes},
  author={Masakiyo Sakaguchi and Masahiro Miyazaki and Mikiro Takaishi and Yoshihiko Sakaguchi and Eiichi Makino and Noriyuki Kataoka and Hidenori Yamada and Masayoshi Namba and Nam-ho Huh},
  journal={The Journal of Cell Biology},
  pages={825 - 835}
An increase in extracellular Ca2+ induces growth arrest and differentiation of human keratinocytes in culture. We examined possible involvement of S100C/A11 in this growth regulation. On exposure of the cells to high Ca2+, S100C/A11 was specifically phosphorylated at 10Thr and 94Ser. Phosphorylation facilitated the binding of S100C/A11 to nucleolin, resulting in nuclear translocation of S100C/A11. In nuclei, S100C/A11 liberated Sp1/3 from nucleolin. The resulting free Sp1/3 transcriptionally… CONTINUE READING
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The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression

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