S100B binding to RAGE in microglia stimulates COX-2 expression.

  title={S100B binding to RAGE in microglia stimulates COX-2 expression.},
  author={Roberta Bianchi and Cecilia Adami and Ileana Giambanco and R. De Donato},
  journal={Journal of leukocyte biology},
  volume={81 1},
Besides exerting regulatory roles within astrocytes, the Ca2+-modulated protein of the EF-hand type S100B is released into the brain extracellular space, thereby affecting astrocytes, neurons, and microglia. However, extracellular effects of S100B vary, depending on the concentration attained and the protein being trophic to neurons up to nanomolar concentrations and causing neuronal apoptosis at micromolar concentrations. Effects of S100B on neurons are transduced by receptor for advanced… CONTINUE READING

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