S100A4 antisense oligodeoxynucleotide suppresses invasive potential of neuroblastoma cells.

@article{Gao2005S100A4AO,
  title={S100A4 antisense oligodeoxynucleotide suppresses invasive potential of neuroblastoma cells.},
  author={Xiao-ning Gao and Suo-qin Tang and Xiaofei Zhang},
  journal={Journal of pediatric surgery},
  year={2005},
  volume={40 4},
  pages={648-52}
}
BACKGROUND S100A4 gene product has been implicated in tumor invasion and metastasis. The overall survival rate of children with neuroblastoma remains poor because of disease dissemination at the time of diagnosis. The purpose of this study was to investigate the effect and mechanism of S100A4 on invasion and metastasis of neuroblastoma. METHODS A 20-mer phosphorothioate antisense oligodeoxynucleotide (asODN) targeted against the S100A4 mRNA was transfected into the human neuroblastoma cell… CONTINUE READING
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