S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.

@article{Mandinova2003S100A13MT,
  title={S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.},
  author={Anna Mandinova and Raffaella Soldi and Irene Graziani and Cinzia Bagal{\'a} and Stephen C Bellum and Matteo Landriscina and Francesca Tarantini and Igor A. Prudovsky and Thomas Maciag},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 13},
  pages={2687-96}
}
Copper is involved in the promotion of angiogenic and inflammatory events in vivo and, although recent clinical data has demonstrated the potential of Cu2+ chelators for the treatment of cancer in man, the mechanism for this activity remains unknown. We have previously demonstrated that the signal peptide-less angiogenic polypeptide, FGF1, uses intracellular Cu2+ to facilitate the formation of a multiprotein aggregate that enables the release of FGF1 in response to stress and that the… CONTINUE READING

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