S100A11, a dual growth regulator of epidermal keratinocytes

  title={S100A11, a dual growth regulator of epidermal keratinocytes},
  author={Masakiyo Sakaguchi and Nam-ho Huh},
  journal={Amino Acids},
S100A11, a member of the family of S100 proteins, is a dimmer, each monomer of which has two EF-hands. Expression of S100A11 is ubiquitous in various tissues at different levels, with a high expression level in the skin. We have analyzed functions of S100A11 mainly in normal human keratinocytes (NHK) as a model cell system of human epithelial cells. High Ca2+ and transforming growth factor-β (TGF-β), two representative growth suppressors for NHK, need a common S100A11-mediated pathway in… CONTINUE READING


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