S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes.

@article{Kettlewell2005S100A1IT,
  title={S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes.},
  author={Sarah L Kettlewell and P. F. J. van der Most and Susan L. Currie and Walter J Koch and Godfrey L. Smith},
  journal={Journal of molecular and cellular cardiology},
  year={2005},
  volume={39 6},
  pages={900-10}
}
The effect of S100A1 protein on cardiac excitation-contraction (E-C) coupling was studied using recombinant human S100A1 protein (0.01-10 microM) introduced into single rabbit ventricular cardiomyocytes via a patch pipette. Voltage clamp experiments (20 degrees C) indicated that 0.1 microM S100A1 increased Ca(2+) transient amplitude by approximately 41% but higher or lower S100A1 concentrations had no significant effect. L-type Ca(2+) current amplitude or Ca(2+) efflux rates via the Na(+)/Ca(2… CONTINUE READING
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