S100A1 gene therapy for heart failure: a novel strategy on the verge of clinical trials.

  title={S100A1 gene therapy for heart failure: a novel strategy on the verge of clinical trials.},
  author={David Rohde and Henriette L Brinks and Julia Ritterhoff and Gang Qui and Shumei Ren and P. F. J. van der Most},
  journal={Journal of molecular and cellular cardiology},
  volume={50 5},
Representing the common endpoint of various cardiovascular disorders, heart failure (HF) shows a dramatically growing prevalence. As currently available therapeutic strategies are not capable of terminating the progress of the disease, HF is still associated with a poor clinical prognosis. Among the underlying molecular mechanisms, the loss of cardiomyocyte Ca(2+) cycling integrity plays a key role in the pathophysiological development and progression of the disease. The cardiomyocyte EF-hand… CONTINUE READING


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