S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers.

@article{Eryilmaz2015S100A1AA,
  title={S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers.},
  author={Ufuk Eryilmaz and Buket Demirci and S Apakkan Aksun and Murat Boyacioğlu and Cagdas Akgullu and Tevfik Fikret Ilgenli and Hande Sultan Yalinkilinc and Mehmet Bilgen},
  journal={PloS one},
  year={2015},
  volume={10 12},
  pages={e0145418}
}
This study examined the value of blood marker S100A1 in detecting cardiotoxicity induced by chemotherapy agents; trastuzumab and lapatinib, in normal rat heart. The rats were divided into three groups: control (n = 8, no treatment), T (n = 8, one time ip treatment with 10 mg/kg trastuzumab) and L (n = 8, oral treatment with 100 mg/kg/day lapatinib for 7 days). The activities of oxidative stress parameters Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH… CONTINUE READING
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