S100 proteins interact with the N-terminal domain of MDM2.

  title={S100 proteins interact with the N-terminal domain of MDM2.},
  author={Jan van Dieck and Jenifer K. Lum and Daniel P. Teufel and A. R. Fersht},
  journal={FEBS letters},
  volume={584 15},
S100 proteins interact with the transactivation domain and the C-terminus of p53. Further, S100B has been shown to interact with MDM2, a central negative regulator of p53. Here, we show that S100B bound directly to the folded N-terminal domain of MDM2 (residues 2-125) by size exclusion chromatography and surface plasmon resonance experiments. This interaction with MDM2 (2-125) is a general feature of S100 proteins; S100A1, S100A2, S100A4 and S100A6 also interact with MDM2 (2-125). These… CONTINUE READING
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