S100 protein immunoreactivity in poorly differentiated carcinomas. Immunohistochemical comparison with malignant melanoma.

@article{Drier1987S100PI,
  title={S100 protein immunoreactivity in poorly differentiated carcinomas. Immunohistochemical comparison with malignant melanoma.},
  author={J K Drier and Paul E. Swanson and David L. Cherwitz and Mark R. Wick},
  journal={Archives of pathology & laboratory medicine},
  year={1987},
  volume={111 5},
  pages={447-52}
}
This study compares the immunoprofiles of 25 cutaneous and mucosal melanomas with those of 400 poorly differentiated carcinomas, using a polyclonal antiserum to S100 and murine monoclonal antibodies to keratin (KER) and epithelial membrane antigen (EMA). All malignant melanomas expressed S100 but lacked reactivity for KER and EMA. Conversely, all of 49… CONTINUE READING