S100-annexin complexes: some insights from structural studies.

Abstract

Several annexins have been shown to bind proteins that belong to the S100 calcium-binding protein family. The two best-characterized complexes are annexin II with p11 and annexin I with S100C, the former of which has been implicated in membrane fusion processes. We have solved the crystal structures of the complexes of p11 with annexin II N-terminus and of S100C with annexin I N-terminus. Using these structural results, as well as electron microscopy observations of liposome junctions formed in the presence of such complexes (Lambert et al., 1997 J Mol Biol 272, 42-55), we propose a computer generated model for the entire annexin II/p11 complex.

Statistics

0100200300'03'05'07'09'11'13'15'17
Citations per Year

655 Citations

Semantic Scholar estimates that this publication has 655 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{LewitBentley2000S100annexinCS, title={S100-annexin complexes: some insights from structural studies.}, author={A Lewit-Bentley and S R{\'e}ty and J Sopkova-de Oliveira Santos and V Gerke}, journal={Cell biology international}, year={2000}, volume={24 11}, pages={799-802} }