S100-annexin complexes: some insights from structural studies.


Several annexins have been shown to bind proteins that belong to the S100 calcium-binding protein family. The two best-characterized complexes are annexin II with p11 and annexin I with S100C, the former of which has been implicated in membrane fusion processes. We have solved the crystal structures of the complexes of p11 with annexin II N-terminus and of S100C with annexin I N-terminus. Using these structural results, as well as electron microscopy observations of liposome junctions formed in the presence of such complexes (Lambert et al., 1997 J Mol Biol 272, 42-55), we propose a computer generated model for the entire annexin II/p11 complex.


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@article{LewitBentley2000S100annexinCS, title={S100-annexin complexes: some insights from structural studies.}, author={A Lewit-Bentley and S R{\'e}ty and J Sopkova-de Oliveira Santos and V Gerke}, journal={Cell biology international}, year={2000}, volume={24 11}, pages={799-802} }