S100 Alone Has the Same Destructive Effect on Retinal Ganglion Cells as in Combination with HSP 27 in an Autoimmune Glaucoma Model

@article{Casola2014S100AH,
  title={S100 Alone Has the Same Destructive Effect on Retinal Ganglion Cells as in Combination with HSP 27 in an Autoimmune Glaucoma Model},
  author={Christina Casola and Jennifer E. Schiwek and Sabrina Reinehr and Sandra Kuehn and Franz Herman Grus and Matthias Kramer and Hans Burkhard Dick and Stephanie C Joachim},
  journal={Journal of Molecular Neuroscience},
  year={2014},
  volume={56},
  pages={228-236}
}
As previously shown, immunization with ocular antigens, like heat shock protein 27 (HSP 27), leads to retinal ganglion cell loss in an autoimmune glaucoma model. Aim of this study was to assess how immunization with S100 alone and in combination with HSP 27 affects retinal ganglion and macroglia cells. Rats were immunized with S100 or S100 plus HSP 27 (COMB). Neuronal cell density was evaluated on Nissl-stained flatmounts. Immunized groups showed a significant neuronal cell loss (S100, p = 0… CONTINUE READING
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