S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation

  title={S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation},
  author={Dorothee Viemann},
  journal={Frontiers in Immunology},
  • D. Viemann
  • Published 30 April 2020
  • Biology
  • Frontiers in Immunology
The restricted capacity of newborn infants to mount inflammatory responses toward microbial challenges has traditionally been linked to the high risk of septic diseases during the neonatal period. In recent years, substantial evidence has been provided that this characteristic of the neonatal immune system is actually a meaningful physiologic state that is based on specific transiently active cellular and molecular mechanisms and required for a favorable course of postnatal immune adaptation… 

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