S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.

@article{Donato2001S100AM,
  title={S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.},
  author={Rosario Donato},
  journal={The international journal of biochemistry & cell biology},
  year={2001},
  volume={33 7},
  pages={
          637-68
        }
}
S100 is a multigenic family of non-ubiquitous Ca(2+)-modulated proteins of the EF-hand type expressed in vertebrates exclusively and implicated in intracellular and extracellular regulatory activities. Within cells, most of S100 members exist in the form of antiparallelly packed homodimers (in some cases heterodimers), capable of functionally crossbridging two homologous or heterologous target proteins in a Ca(2+)-dependent (and, in some instances, Ca(2+)-independent) manner. S100 oligomers can… CONTINUE READING
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