S1 ribosomal protein functions in translation initiation and ribonuclease RegB activation are mediated by similar RNA-protein interactions: an NMR and SAXS analysis.

@article{Aliprandi2008S1RP,
  title={S1 ribosomal protein functions in translation initiation and ribonuclease RegB activation are mediated by similar RNA-protein interactions: an NMR and SAXS analysis.},
  author={Pascale Aliprandi and Christina Sizun and Javier de Cruz P{\'e}rez and Fabien Mareuil and Sandrine Caputo and J A Leroy and Beno{\^i}t Odaert and Soumaya Laalami and Marc Uzan and François Bontems},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 19},
  pages={13289-301}
}
The ribosomal protein S1, in Escherichia coli, is necessary for the recognition by the ribosome of the translation initiation codon of most messenger RNAs. It also participates in other functions. In particular, it stimulates the T4 endoribonuclease RegB, which inactivates some of the phage mRNAs, when their translation is no longer required, by cleaving them in the middle of their Shine-Dalgarno sequence. In each function, S1 seems to target very different RNAs, which led to the hypothesis… CONTINUE READING
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