S021-05 OA. Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface

@article{Song2009S02105OB,
  title={S021-05 OA. Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface},
  author={Lei Song and ZJ Sun and KE Coleman and M Zwick and JS Gach and Jiexin Wang and EL Reinherz and Gerhard Wagner and Mikyung Kim},
  journal={Retrovirology},
  year={2009},
  volume={6},
  pages={O5 - O5}
}
A vaccine capable of stimulating protective antiviral antibody responses is needed to curtail the global AIDS epidemic caused by HIV-1. Although rarely elicited during the course of natural infection or upon conventional vaccination, the membrane-proximal ectodomain region (MPER) of the HIV-1 glycoprotein of M(r) 41,000 (gp41) envelope protein subunit is the target of 3 such human broadly neutralizing antibodies (BNAbs): 4E10, 2F5, and Z13e1. How these BNAbs bind to their lipid-embedded… CONTINUE READING