S.01.02 Proteomics and phosphoproteomics for understanding cellular signalling and its disruption in CNS disorders

@article{Marn2014S0102PA,
  title={S.01.02 Proteomics and phosphoproteomics for understanding cellular signalling and its disruption in CNS disorders},
  author={P Barreiro Mar{\'i}n and Franck Vandermoere and S{\'e}verine Chaumont-Dubel and Mark John Millan and Jo{\"e}l Bockaert},
  journal={European Neuropsychopharmacology},
  year={2014},
  volume={24},
  pages={s2-s3}
}
data published by Braak and colleagues. Based on their analysis of postmortem human brains in the age range of 1–100 years, they reported that tau-related neuronal changes appear first in the locus coeruleus, a crucial brain stem nucleus implicated in stress response regulation. The following area to be affected with increasing age is the transentorhinal cortex with its axonal projections from Reelin-expressing cells located in the olfactory bulb. The reduction of Reelin, as a consequence of… CONTINUE READING
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