S. cerevisiae α pheromone receptors activate a novel signal transduction pathway for mating partner discrimination

@article{Jackson1991SC,
  title={S. cerevisiae α pheromone receptors activate a novel signal transduction pathway for mating partner discrimination},
  author={Catherine L. Jackson and James B Konopka and Leland H. Hartwell},
  journal={Cell},
  year={1991},
  volume={67},
  pages={389-402}
}
Wild-type S. cerevisiae cells of both mating types prefer partners producing high levels of pheromone and mate very infrequently to cells producing no pheromone. However, some mutants that are supersensitive to pheromone lack this ability to discriminate. In this study, we provide evidence for a novel role of alpha pheromone receptors in mating partner discrimination that is independent of the known G protein-mediated signal transduction pathway. Furthermore, in response to pheromone, receptors… CONTINUE READING
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