S-phase lengthening induced by p16(INK4a) overexpression in malignant cells with wild-type pRb and p53.

@article{Chien2010SphaseLI,
  title={S-phase lengthening induced by p16(INK4a) overexpression in malignant cells with wild-type pRb and p53.},
  author={Wei Wen Chien and Carine Domenech and R{\'e}gine Catallo and Gilles Salles and Martine Ffrench},
  journal={Cell cycle},
  year={2010},
  volume={9 16},
  pages={3286-96}
}
The p16(INK4a) protein is considered to regulate the cell cycle progression mainly by inhibiting cyclin-dependent kinases (CDKs) 4 and 6 activity and leading to an arrest in G(0)/G(1). Here, we report that ectopic expression of p16(INK4a) in three p16-/pRb(Wt)/p53(Wt) human cancer cell lines MCF7, U2OS and U87 induces S-phase lengthening along with G(1) accumulation. S-phase lengthening is suggested by the discrepancy between the unchanged or even increased percentage of cells in S phase found… CONTINUE READING
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