S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo

@inproceedings{Wu2009SphaseKP,
  title={S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo},
  author={Yih-Jer Wu and Graciela B. Sala-Newby and Kuo-Tung Shu and Hung-I. Yeh and Keiichi I Nakayama and Keiko Nakayama and Andrew C Newby and Mark Bond},
  booktitle={Journal of vascular surgery},
  year={2009}
}
OBJECTIVE Vascular smooth muscle cell (VSMC) proliferation plays an important role in the development of postangioplasty or in-stent restenosis, venous graft failure, and atherosclerosis. Our previous work has demonstrated S-phase kinase-associated protein-2 (Skp2), an F-box subunit of SCF(Skp2) ubiquitin ligase, as an important mediator and common final pathway for growth factors, extracellular matrices, and cyclic-nucleotides to regulate VSMC proliferation in vitro. However, whether… CONTINUE READING