S-phase fraction and breast cancer - a decade of experience

  title={S-phase fraction and breast cancer - a decade of experience},
  author={Charlotte R. Wenger and G. M. G. Clark},
  journal={Breast Cancer Research and Treatment},
During the past decade, more than 300 articles, abstracts, and book chapters have been published about S-phase fraction (SPF) determined by DNA flow cytometry and its clinical utility for patients with breast cancer. However, the use of SPF for making treatment decisions for breast cancer patients remains controversial. After reviewing 273 published articles, we conclude: 1) Despite different techniques and cutpoints, correlations between SPF and other prognostic markers are relatively… CONTINUE READING