S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance

@article{Zhang2011SPI,
  title={S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance},
  author={Jiqin Zhang and Qinqin Gao and Pishun Li and Xiaoli Liu and Yuanhui Jia and Weicheng Wu and Jiwen Li and Shuo Dong and Haruhiko Koseki and Jiemin Wong},
  journal={Cell Research},
  year={2011},
  volume={21},
  pages={1723-1739}
}
Recent studies demonstrate that UHRF1 is required for DNA methylation maintenance by targeting DNMT1 to DNA replication foci, presumably through its unique hemi-methylated DNA-binding activity and interaction with DNMT1. UHRF2, another member of the UHRF family proteins, is highly similar to UHRF1 in both sequence and structure, raising questions about its role in DNA methylation. In this study, we demonstrate that, like UHRF1, UHRF2 also binds preferentially to methylated histone H3 lysine 9… CONTINUE READING
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