S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid.

Abstract

The addition of all-trans-retinoic acid has been found to mediate a G1 cell cycle phase arrest but not apoptosis in normal mammary epithelial cells. We have now found that addition of the novel retinoid 6-[3-(1-adamantyl)]-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437), which appears to function through a pathway independent of retinoic acid nuclear… (More)

10 Figures and Tables

Topics

  • Presentations referencing similar topics