S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease.

@article{Haun2013SnitrosylationOD,
  title={S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease.},
  author={Florian Haun and Tomohiro Nakamura and Alicia D Shiu and Dong-Hyung Cho and Taiji Tsunemi and Emily A. Holland and Albert R La Spada and Stuart Lipton},
  journal={Antioxidants & redox signaling},
  year={2013},
  volume={19 11},
  pages={1173-84}
}
AIMS Dynamin-related protein1 (Drp1) is a large GTPase that mediates mitochondrial fission. We recently reported in Alzheimer's disease (AD) that S-nitrosylation of Drp1 (forming S-nitroso [SNO]-Drp1) results in GTPase hyperactivity and mitochondrial fragmentation, thus impairing bioenergetics and inducing synaptic damage and neuronal loss. Here, since aberrant mitochondrial dynamics are also key features of Huntington's disease (HD), we investigated whether formation of SNO-Drp1 contributes to… CONTINUE READING

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