S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis.

  title={S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis.},
  author={Wei Wei and Bin Li and Martha A. Hanes and Sanjay Kakar and Xin Mao Chen and Limin Liu},
  journal={Science translational medicine},
  volume={2 19},
Human hepatocellular carcinoma (HCC) is associated with elevated expression of inducible nitric oxide synthase (iNOS), but the role of nitric oxide in the pathogenesis of HCC remains unknown. We found that the abundance and activity of S-nitrosoglutathione reductase (GSNOR), a protein critical for control of protein S-nitrosylation, were significantly decreased in approximately 50% of patients with HCC. GSNOR-deficient mice were very susceptible to spontaneous and carcinogen-induced HCC. During… CONTINUE READING
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