S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood.

@article{Reynolds2007SnitrosohemoglobinDA,
  title={S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood.},
  author={James D. Reynolds and Gregory S. Ahearn and Michael Angelo and Jian Zhang and Fred Cobb and Jonathan S. Stamler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 43},
  pages={17058-62}
}
RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We hypothesized that storage of blood would result in loss of NO bioactivity, impairing RBC vasodilation and thus compromising blood flow, and that repleting NO bioactivity would restore RBC function. We report that S-nitrosohemoglobin (SNO-Hb) concentrations declined rapidly after storage of fresh venous blood and that hypoxic vasodilation by… CONTINUE READING