S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery.

@article{NozikGrayck2006SnitrosoglutathioneIA,
  title={S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery.},
  author={Eva Nozik-Grayck and Erin J. Whalen and Jonathan S. Stamler and Timothy J McMahon and Pasquale Chitano and Claude A. Piantadosi},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={290 1},
  pages={
          L136-43
        }
}
Endogenous nitric oxide donor compounds (S-nitrosothiols) contribute to low vascular tone by both cGMP-dependent and -independent pathways. We have reported that S-nitrosoglutathione (GSNO) inhibits 5-hydroxytryptamine (5-HT)-mediated pulmonary vasoconstriction via a cGMP-independent mechanism likely involving S-nitrosylation of its G protein-coupled… CONTINUE READING