S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance.

  title={S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance.},
  author={M. A. Carvalho-Filho and M. Ueno and S. Hirabara and A. B. Seabra and J. Carvalheira and M. G. de Oliveira and L. Velloso and R. Curi and M. A. Saad},
  volume={54 4},
  • M. A. Carvalho-Filho, M. Ueno, +6 authors M. A. Saad
  • Published 2005
  • Biology, Medicine
  • Diabetes
  • Evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible nitric oxide synthase (iNOS) can induce insulin resistance in muscle. Here, we investigated whether this insulin resistance could be mediated by S-nitrosation of proteins involved in early steps of the insulin signal transduction pathway. Exogenous NO donated by S-nitrosoglutathione (GSNO) induced in vitro and in vivo S-nitrosation of the insulin receptor beta subunit (IRbeta) and protein kinase B/Akt (Akt… CONTINUE READING
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