S-methyl-N,N-diethylthiocarbamate sulfoxide elicits neuroprotective effect against N-methyl-D-aspartate receptor-mediated neurotoxicity.

@article{Ningaraj2001SmethylNNdiethylthiocarbamateSE,
  title={S-methyl-N,N-diethylthiocarbamate sulfoxide elicits neuroprotective effect against N-methyl-D-aspartate receptor-mediated neurotoxicity.},
  author={N S Ningaraj and Wen-Chi Chen and John V. Schloss and Morris D Faiman and J. Y. Wu},
  journal={Journal of biomedical science},
  year={2001},
  volume={8 1},
  pages={104-13}
}
Glutamatergic neurotransmission, particularly of the NMDA receptor type, has been implicated in the excitotoxic response to several external and internal stimuli. In the present investigation, we report that S-methyl-N,N-diethylthiocarbamate sulfoxide (DETC-MeSO) selectively and specifically blocks the NMDA receptor subtype of the glutamate receptors, and… CONTINUE READING