S-glutathionylation of troponin I (fast) increases contractile apparatus Ca2+ sensitivity in fast-twitch muscle fibres of rats and humans.

@article{Mollica2012SglutathionylationOT,
  title={S-glutathionylation of troponin I (fast) increases contractile apparatus Ca2+ sensitivity in fast-twitch muscle fibres of rats and humans.},
  author={Janelle P. Mollica and Travis L. Dutka and Troy L. Merry and Cedric R Lamboley and Glenn Kevin McConell and Michael J. McKenna and Robyn M Murphy and G. D. Lamb},
  journal={The Journal of physiology},
  year={2012},
  volume={590 6},
  pages={1443-63}
}
Oxidation can decrease or increase the Ca2+ sensitivity of the contractile apparatus in rodent fast-twitch (type II) skeletal muscle fibres, but the reactions and molecular targets involved are unknown. This study examined whether increased Ca2+ sensitivity is due to S-glutathionylation of particular cysteine residues. Skinned muscle fibres were directly activated in heavily buffered Ca2+ solutions to assess contractile apparatus Ca2+ sensitivity. Rat type II fibres were subjected to S… CONTINUE READING

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