S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration.

@article{Abdelsaid2012SglutathionylationOL,
  title={S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration.},
  author={Mohammed A. Abdelsaid and Azza B El-Remessy},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 20},
  pages={4751-60}
}
Although promising, the ability to regulate angiogenesis through delivery of VEGF remains an unrealized goal. We have shown previously that physiological levels of peroxynitrite (1 µM) are required for a VEGF-mediated angiogenic response, yet the redox-regulated mechanisms that govern the VEGF signal remain unexplored. We assessed the impact of VEGF and peroxynitrite on modifying redox-state, the level of reduced-glutathione (GSH) and S-glutathionylation on regulation of the low molecular… CONTINUE READING
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