S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora.

@article{Setchell2005SequolAP,
  title={S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora.},
  author={Kenneth D. R. Setchell and Carlo Alfredo Clerici and Edwin D Lephart and Sidney J Cole and Claire Heenan and Danilo Castellani and Brian E Wolfe and Linda Nechemias-Zimmer and Nadine Maynard Brown and Trent D. Lund and Robert J. Handa and James E. Heubi},
  journal={The American journal of clinical nutrition},
  year={2005},
  volume={81 5},
  pages={1072-9}
}
BACKGROUND The discovery of equol in human urine more than 2 decades ago and the finding that it is bacterially derived from daidzin, an isoflavone abundant in soy foods, led to the current nutritional interest in soy foods. Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers. OBJECTIVE Because it was unclear which enantiomer was present in humans, our objectives were to characterize the exact structure of equol… CONTINUE READING
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