S-allyl-L-cysteine selectively protects cultured rat hippocampal neurons from amyloid beta-protein- and tunicamycin-induced neuronal death.

@article{Kosuge2003SallylLcysteineSP,
  title={S-allyl-L-cysteine selectively protects cultured rat hippocampal neurons from amyloid beta-protein- and tunicamycin-induced neuronal death.},
  author={Yasuhiro Kosuge and Yakov M. Koen and Kumiko Ishige and Kentaro Minami and H Urasawa and Hiroshi Saito and Yasuhiro Ito},
  journal={Neuroscience},
  year={2003},
  volume={122 4},
  pages={885-95}
}
S-allyl-L-cysteine (SAC), one of the organosulfur compounds found in aged garlic extract, has been shown to possess various biological effects including neurotrophic activity. In our previous experiments, we found that SAC could protect against amyloid beta-protein (Abeta)- and tunicamycin-induced cell death in differentiated PC12 cells. In the study described here, we characterized the neuronal death induced by Abeta, 4-hydroxynonenal (HNE), tunicamycin, and trophic factor deprivation, and… CONTINUE READING
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