S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei.

  title={S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei.},
  author={Nigel Yarlett and Joe Garofalo and Brett R Goldberg and M A Ciminelli and V Florence Ruggiero and Janice R. Sufrin and Cyrus J. Bacchi},
  journal={Biochimica et biophysica acta},
  volume={1181 1},
S-adenosylmethionine synthetase was studied from bloodstream forms of Trypanosoma brucei brucei, the agent of African sleeping sickness. Two isoforms of the enzyme were evident from Eadie Hofstee and Hanes-Woolf plots of varying ATP or methionine concentrations. In the range 10-250 microM the Km for methionine was 20 microM, and this changed to 200 microM for the range 0.5-5.0 mM. In the range 10-250 microM the Km for ATP was 53 microM, and this changed to 1.75 mM for the range 0.5-5.0 mM. The… CONTINUE READING
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