S-adenosylmethionine inhibits the activated phenotype of human hepatic stellate cells via Rac1 and matrix metalloproteinases.

@article{Zhang2014SadenosylmethionineIT,
  title={S-adenosylmethionine inhibits the activated phenotype of human hepatic stellate cells via Rac1 and matrix metalloproteinases.},
  author={Feng Zhang and Yu-zheng Zhuge and Yu-Jiang Li and Jian-Xiang Gu},
  journal={International immunopharmacology},
  year={2014},
  volume={19 2},
  pages={193-200}
}
OBJECTIVE To investigate the effects of S-adenosylmethionine (SAM) on the proliferation, adhesion, migration, invasion and apoptosis of activated human hepatic stellate cells (HSCs) and to explore the relevant potential mechanisms. METHODS Human HSCs LX-2 were cultured with SAM. The proliferation and adhesion were detected by CCK-8. Cell apoptosis rate were analyzed by flow cytometry, and cell migration and invasion were tested by the transwell assay. The expression of Rac1 and MMP-2 was… CONTINUE READING

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