S-adenosylhomocysteine treatment of adult female fibroblasts alters X-chromosome inactivation and improves in vitro embryo development after somatic cell nuclear transfer.

@article{Jeon2008SadenosylhomocysteineTO,
  title={S-adenosylhomocysteine treatment of adult female fibroblasts alters X-chromosome inactivation and improves in vitro embryo development after somatic cell nuclear transfer.},
  author={Byeong-Gyun Jeon and Gianfranco Coppola and Steven D. Perrault and Gyu-Jin Rho and Dean H. Betts and William Allan King},
  journal={Reproduction},
  year={2008},
  volume={135 6},
  pages={
          815-28
        }
}
The poor outcome of somatic cell nuclear transfer (SCNT) is thought to be a consequence of incomplete reprogramming of the donor cell. The objective of this study was to investigate the effects of treatment with S-adenosylhomocysteine (SAH) a DNA demethylation agent, on DNA methylation levels and X-chromosome inactivation status of bovine female fibroblast donor cells and the subsequent impact on developmental potential after SCNT. Compared with non-treated controls, the cells treated with SAH… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 79 REFERENCES

Mechanisms of X-chromosome inactivation.

  • Frontiers in bioscience : a journal and virtual library
  • 2006
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Epigenetic reprogramming in mammals.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Aberrant patterns of X chromosome inactivation in bovine clones

  • Nature Genetics
  • 2002
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
VIEW 7 EXCERPTS