S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis.

@article{Ratter1996SadenosylhomocysteineAA,
  title={S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis.},
  author={F. Ratter and M. Germer and T. Fischbach and K. Schulze-Osthoff and M. Peter and W. Dröge and P. Krammer and V. Lehmann},
  journal={International immunology},
  year={1996},
  volume={8 7},
  pages={
          1139-47
        }
}
APO-1/Fas (CD95) is a member of the tumor necrosis factor/nerve growth factor receptor superfamily and mediates apoptosis in various cell types. Here we show that L929 cells, expressing human APO-1 treated with agonistic antibodies (anti-APO-1), elicit an early and transient increase of S-adenosylhomocysteine (AdoHcy), a potent inhibitor of S-adenosylmethionine (AdoMet)-dependent methylation reactions. In contrast, anti-APO-1 did not induce an AdoHcy increase in L929-APO-1 Delta4 cells… Expand
Purines and their roles in apoptosis
FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC)
Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.
Molecular Ordering of the Initial Signaling Events of CD95
...
1
2
3
4
...

References

SHOWING 1-10 OF 54 REFERENCES
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase
...
1
2
3
4
5
...