S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon.

  title={S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon.},
  author={Charles S. Lieber and A Casini and Leonore M Decarli and Chung Il Kim and N Lowe and Rie Sasaki and Maria Anna Leo},
  volume={11 2},
Chronic ethanol consumption by baboons (50% of energy from a liquid diet) for 18 to 36 mo resulted in significant depletion of hepatic S-adenosyl-L-methionine concentration: 74.6 +/- 2.4 nmol/gm vs. 108.9 +/- 8.2 nmol/gm liver in controls (p less than 0.005). The depletion was corrected with S-adenosyl-L-methionine (0.4 mg/kcal) administration (102.1 +/- 15.4 nmol/gm after S-adenosyl-L-methionine-ethanol, with 121.4 +/- 11.9 nmol/gm in controls). Ethanol also induced a depletion of glutathione… CONTINUE READING


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