S-Nitrosylation of NSF Controls Membrane Trafficking

  title={S-Nitrosylation of NSF Controls Membrane Trafficking},
  author={Thomas H. S{\"o}llner and Sonia M. Sequeira},
Nitric oxide is a diffusible molecule with profound effects on regulated exocytosis in several biological systems-however, the molecular targets remain elusive. In this issue of Cell, Matsushita et al. report that in aortic endothelial cells, S-nitrosylation of NSF, an ATPase essential for the activation of the membranefusion machinery, inhibits the exocytosis of Weibel-Palade bodies, secretory granules containing a cocktail of mediators essential to the regulation of vascular vessel tone.