S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells.

@article{Wu2014SNitrosylatingPD,
  title={S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells.},
  author={Xiaofang Wu and A Wang and Ling Chen and En-ping Huang and Wei-bing Xie and Chao Liu and W Q Huang and Chuan-xiang Chen and Ping-ming Qiu and Hongyan Wang},
  journal={Toxicology letters},
  year={2014},
  volume={230 1},
  pages={19-27}
}
Methamphetamine (METH) belongs to Amphetamine-type stimulants, METH abusers are at high risk of neurodegenerative disorders, including Parkinson's disease (PD). However, there are still no effective treatments to METH-induced neurodegeneration because its mechanism remains unknown. In order to investigate METH's neurotoxic mechanism, we established an in vitro PD pathology model by exposing PC12 cells to METH. We found the expression of nitric oxide synthase (NOS), nitric oxide (NO) and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…