S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase.

  title={S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase.},
  author={Neil Hogg and Ravinder Jit Singh and Eugene A Konorev and Joy Joseph and Balaraman Kalyanaraman},
  journal={The Biochemical journal},
  volume={323 ( Pt 2)},
S-Nitrosoglutathione (GSNO) has been used as a nitric oxide (.NO) donor compound and has also been postulated to be involved in the transport of .NO in vivo. In this study we have examined the possibility that GSNO is a substrate for gamma-glutamyl transpeptidase (gamma-GT), an enzyme that hydrolyses the gamma-glutamyl moiety of glutathione to give glutamate and cysteinylglycine. gamma-GT accelerated the decomposition of GSNO, forming S-nitrosocysteinylglycine (CG-SNO) by a mechanism… CONTINUE READING


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