S-Nitrosoglutathione and glutathione act as NMDA receptor agonists in cultured hippocampal neurons

@article{Chin2006SNitrosoglutathioneAG,
  title={S-Nitrosoglutathione and glutathione act as NMDA receptor agonists in cultured hippocampal neurons},
  author={Ting-yu Chin and Sheau-Huei Chueh and Pao-luh Tao},
  journal={Acta Pharmacologica Sinica},
  year={2006},
  volume={27},
  pages={853-860}
}
AbstractAim:To characterize the effect of combined pre- and postnatal morphine exposure on N-methyl-D-aspartate receptor (NMDA) receptor signaling in hippocampal neurons of the offspring of morphine-addicted female rats.Methods:Cultured hippocampal neurons and synaptosomes were prepared from neonatal and 2- week-old offspring, respectively, of control or morphine-addicted female rats. The increase in the cytosolic Ca2+ concentration ([Ca2+]i) of cultured cells was measured using Fura-2, and… CONTINUE READING

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