S ICK : Implications of Immune-to-Brain Communication for Understanding Pain

@inproceedings{Watkins2010SI,
  title={S ICK : Implications of Immune-to-Brain Communication for Understanding Pain},
  author={Linda R. Watkins and Steven F. Maier},
  year={2010}
}
This review focuses on the powerful pain facilitatory effects produced by the immune system. Immune cells, activated in response to infection, inflammation, or trauma, release proteins called proinflammatory cytokines. These proinflammatory cytokines signal the central nervous system, thereby creating exaggerated pain as well as an entire constellation of… CONTINUE READING